MGMT analysis at DNA, RNA and protein levels in glioblastoma tissue.

@article{Preusser2009MGMTAA,
  title={MGMT analysis at DNA, RNA and protein levels in glioblastoma tissue.},
  author={Matthias Preusser},
  journal={Histology and histopathology},
  year={2009},
  volume={24 4},
  pages={
          511-8
        }
}
Evidence from several studies supports that the epigenetic, transcriptional and translational regulation and expression of O6-methylguanine-methyltransferase (MGMT) is relevant for prognostic and predictive considerations in glioblastoma patients. MGMT status is being used as a stratifying factor or eligibility criterion in ongoing and accruing clinical glioblastoma trials. In some cases, there is also interest in MGMT assessment of glioblastoma tissue in the day-to-day clinical setting… CONTINUE READING

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