MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

@article{Kaina2007MGMTKN,
  title={MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.},
  author={Bernd Kaina and Markus Christmann and Steffen C. Naumann and Wynand Paul Roos},
  journal={DNA repair},
  year={2007},
  volume={6 8},
  pages={1079-99}
}
O(6)-methylguanine-DNA methyltransferase (MGMT) plays a crucial role in the defense against alkylating agents that generate, among other lesions, O(6)-alkylguanine in DNA (collectively termed O(6)-alkylating agents [O(6)AA]). The defense is highly important, since O(6)AA are common environmental carcinogens, are formed endogenously during normal cellular metabolism and possibly inflammation, and are being used in cancer therapy. O(6)AA induced DNA damage is subject to repair, which is executed… CONTINUE READING
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