MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of β-catenin

@article{Jllig2006MG132IA,
  title={MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of β-catenin},
  author={M. J{\"u}llig and Wei Zhang and Ana L{\'i}via da S Ferreira and N. Susan Stott},
  journal={Apoptosis},
  year={2006},
  volume={11},
  pages={627-641}
}
Noxa is a pro-apoptotic BH3-only member of the Bcl-2 family of proteins that is up-regulated at a transcriptional level by the nuclear protein p53 in response to cellular stresses such as DNA damage or growth factor deprivation. Noxa is able to interact with anti-apoptotic members of the Bcl-2 family and causes release of cytochrome c into the cytosol… CONTINUE READING