MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis.

  title={MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis.},
  author={Melanie Neutzner and Theresa Lopez and Xu Feng and Elke S. Bergmann-Leitner and W. Leitner and Mark C. Udey},
  journal={Cancer research},
  volume={67 14},
The relevance of angiogenesis in tumor biology and as a therapeutic target is well established. MFG-E8 (also termed lactadherin) and developmental endothelial locus 1 (Del1) constitute a two-gene family of alpha(v)beta(3)/beta(5) ligands that regulate angiogenesis. After detecting MFG-E8 mRNA in murine tumor cell lines, we sought to determine if MFG-E8 influenced tumorigenesis in Rip1-Tag2 transgenic mice, a cancer model in which angiogenesis is critical. MFG-E8 mRNA and protein were increased… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 36 extracted citations

Milk Fat Globule-Epidermal Growth Factor 8 (MFG-E8) Is a Novel Anti-inflammatory Factor in Rheumatoid Arthritis in Mice and Humans.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research • 2016
View 1 Excerpt

Protective effect of MFG-E8 after cutaneous ischemia-reperfusion injury.

The Journal of investigative dermatology • 2015
View 3 Excerpts


Publications referenced by this paper.
Showing 1-10 of 33 references

Lactadherin promotes VEGF-dependent neovascularization

Nature Medicine • 2005
View 3 Excerpts
Highly Influenced

Cloning and Cancer

C Hidai, T Zupancic, K Penta
Research Cancer Res • 2007
View 1 Excerpt

Integrin signalling during tumour progression

Nature Reviews Molecular Cell Biology • 2004
View 1 Excerpt

Similar Papers

Loading similar papers…