MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis.

@article{Neutzner2007MFGE8lactadherinPT,
  title={MFG-E8/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis.},
  author={Melanie Neutzner and Theresa Lopez and Xu Feng and Elke S. Bergmann-Leitner and W. Leitner and Mark C. Udey},
  journal={Cancer research},
  year={2007},
  volume={67 14},
  pages={6777-85}
}
The relevance of angiogenesis in tumor biology and as a therapeutic target is well established. MFG-E8 (also termed lactadherin) and developmental endothelial locus 1 (Del1) constitute a two-gene family of alpha(v)beta(3)/beta(5) ligands that regulate angiogenesis. After detecting MFG-E8 mRNA in murine tumor cell lines, we sought to determine if MFG-E8 influenced tumorigenesis in Rip1-Tag2 transgenic mice, a cancer model in which angiogenesis is critical. MFG-E8 mRNA and protein were increased… CONTINUE READING

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