METHOD DEVELOPMENT AND VALIDATION OF BOSENTAN IN BULK AND PHARMACEUTICAL FORMULATION BY USING HPTLC
@inproceedings{Madhuri2016METHODDA, title={METHOD DEVELOPMENT AND VALIDATION OF BOSENTAN IN BULK AND PHARMACEUTICAL FORMULATION BY USING HPTLC}, author={Lakshmi Madhuri and Savita S. Yadav and Chaitali Dhale and Janhavi R Rao}, year={2016} }
In the present study a rapid specific economical HPTLC method has been developed for determination of Bosentan in bulk and pharmaceutical dosage formulation. Chromatographic separation was achieved on aluminum plates precoated with silica gel 60 F254 aluminum plates with mobile phase of methanol: toluene in the ratio of 2: 8(v/v). Detection was performed densitometrically at 225 nm using Camag TLC Scanner. The Rf of Bosentan found to be 0.32.The Method was validated as per ICH guidelines in…
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