• Corpus ID: 212581107

METHOD DEVELOPMENT AND VALIDATION OF BOSENTAN IN BULK AND PHARMACEUTICAL FORMULATION BY USING HPTLC

@inproceedings{Madhuri2016METHODDA,
  title={METHOD DEVELOPMENT AND VALIDATION OF BOSENTAN IN BULK AND PHARMACEUTICAL FORMULATION BY USING HPTLC},
  author={Lakshmi Madhuri and Savita S. Yadav and Chaitali Dhale and Janhavi R Rao},
  year={2016}
}
In the present study a rapid specific economical HPTLC method has been developed for determination of Bosentan in bulk and pharmaceutical dosage formulation. Chromatographic separation was achieved on aluminum plates precoated with silica gel 60 F254 aluminum plates with mobile phase of methanol: toluene in the ratio of 2: 8(v/v). Detection was performed densitometrically at 225 nm using Camag TLC Scanner. The Rf of Bosentan found to be 0.32.The Method was validated as per ICH guidelines in… 

Figures and Tables from this paper

References

SHOWING 1-10 OF 19 REFERENCES
Simple Estimation of Bosentan in Tablet Formulation by RP-HPLC
A simple, precise, and accurate method is developed and validated for the analysis of Bosentan tablet formulation. The method has shown adequate separation of the ingredients from Tablets. Separation
Determination of Bosentan in Pharmaceutical Dosage Forms by High Performance Liquid Chromatography
A simple and sensitive high performance liquid chromatographic method is developed for the estimation of bosentan in pharmaceutical dosage forms. Chromatographic separation of the drug was achieved
New Spectrophotometric Method for the Determination of Bosentan - An Anti-Hypertensive Agent in Pharmaceutical Dosage Forms
A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of Bosentan in bulk and in pharmaceutical formulations. Bosentan exhibits
Review of bosentan in the management of pulmonary arterial hypertension
TLDR
An algorithm is provided to guide the reader in monitoring potential increases in alanine and aspartate transaminase levels that may occur with bosentan use and the dose adjustments that are recommended as a result of any increase in the levels of these enzymes.
Endothelin antagonism with bosentan: a review of potential applications
TLDR
In experimental models of heart failure bosentan acts as a vasodilator and neurohormonal blocker that improves overall left ventricular performance and reduces renal dysfunction, and in chronic studies, bosENTan attenuates cardiac remodeling and significantly improves survival.
Current status of bosentan for treatment of pulmonary hypertension.
TLDR
The pharmacology of bosentan is discussed, the current available evidence for the safety and efficacy of bosENTan for the treatment of PAH is summarized and the benefits and risks of this drug are summarized.
Instrumental methods of chemical analysis
Course Educational Objectives: To make the student understand the advanced instrumentation available for chemical analysis. Course Outcomes: After studying this course the student would be able to
ACCP Evidence-Based Clinical Practice Guidelines
    Develpoment Estimation and Validation of Besantan in Bulk and in its Pharmaceutical Formulation by UV-VIS
    • Spectroscopic method,
    • 2000
    ...
    ...