METHOD DEVELOPMENT, VALIDATION AND STABILITY STUDIES FOR DETERMINATION OF BUMETANIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY RP-UPLC

@article{Boni2018METHODDV,
  title={METHOD DEVELOPMENT, VALIDATION AND STABILITY STUDIES FOR DETERMINATION OF BUMETANIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM BY RP-UPLC},
  author={C. Boni and R. Sundararajan},
  journal={International Journal of Pharmacy and Pharmaceutical Sciences},
  year={2018},
  volume={10},
  pages={35-42}
}
Objective: The objective of the study was to develop a new, simple, accurate, precise and reproducible RP-UPLC method for the estimation of bumetanide in bulk and pharmaceutical dosage form. Methods: Acquity SB C18, 2 x 100 mm, 1.8 µmm, 5m particle size column with the mobile phase consisting of water: acetonitrile in the ratio of 30:70 v/v were used. The effluents were moniRTat 254 nm and the flow rate was 1.0 ml/minute. Results: The retention time was 0.852 min. Quantitative linearity was… Expand

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