METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE α4β2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO

@article{Obach2006METABOLISMAD,
  title={METABOLISM AND DISPOSITION OF VARENICLINE, A SELECTIVE $\alpha$4$\beta$2 ACETYLCHOLINE RECEPTOR PARTIAL AGONIST, IN VIVO AND IN VITRO},
  author={R. Scott Obach and Anne E Reed-Hagen and Suzanne S. Krueger and Beth J. Obach and Thomas N. O'Connell and Kathleen S. Zandi and Sandra A. Miller and Jotham Wadsworth Coe},
  journal={Drug Metabolism and Disposition},
  year={2006},
  volume={34},
  pages={121 - 130}
}
The metabolism and disposition of varenicline (7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine), a partial agonist of the nicotinic acetylcholine receptor for the treatment of tobacco addiction, was examined in rats, mice, monkeys, and humans after oral administration of [14C]varenicline. In the circulation of all species, the majority of drug-related material was composed of unchanged varenicline. In all four species, drug-related material was primarily excreted in the urine… Expand
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