METABOLIC BASIS FOR THE SUPRA‐ADDITIVE EFFECT OF THE ETHANOL‐DIAZEPAM COMBINATION IN MICE

@article{Paul1977METABOLICBF,
  title={METABOLIC BASIS FOR THE SUPRA‐ADDITIVE EFFECT OF THE ETHANOL‐DIAZEPAM COMBINATION IN MICE},
  author={C. J. Paul and Larry W. Whitehouse},
  journal={British Journal of Pharmacology},
  year={1977},
  volume={60}
}
1 The comination of ethanol and diazepam elicits additive or supra‐additive pharmacological effects in animals and humans. Since the mouse appeared to be a reasonably good animal model for man, this species was examined to determine if a biochemical basis for these effects could be established. 2 The effect of ethanol (3 g/kg, orally), administered 0.5 h before [14C]‐diazepam (5 mg/kg, orally), on the pharmacokinetics of diazepam in male Swiss Webster mice was examined. 3 At 4, 6, 8 and 12 h… Expand
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