METABOLIC ASPECTS OF "OROTIC ACID FATTY LIVER". RELATIONSHIPS BETWEEN BIOTIN AND FATTY LIVER.

@article{Marchetti1964METABOLICAO,
  title={METABOLIC ASPECTS OF "OROTIC ACID FATTY LIVER". RELATIONSHIPS BETWEEN BIOTIN AND FATTY LIVER.},
  author={M. Marchetti and P. Puddu},
  journal={Archives of biochemistry and biophysics},
  year={1964},
  volume={108},
  pages={
          468-70
        }
}
Abstract The effect of dietary administration of 1% orotic acid on the biotin content of liver as well as the influence of biotin deficiency on the development of fatty liver in orotic acid-treated rats have been studied. The amount of biotin in the livers of orotic acid-fed rats was lower than in the controls. In biotin-deficient rats, the development of orotic acid fatty liver was inhibited while the administration of large doses of biotin led to an increase of liver fat. The data suggest… Expand
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