MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.

@article{Luraghi2014METSI,
  title={MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.},
  author={Paolo Luraghi and Gigliola Reato and Elia Cipriano and Francesco P. Sassi and Francesca N Orzan and Viola Bigatto and Francesca De Bacco and Elena Menietti and May Sabai Han and William M. Rideout and Timothy P S Perera and Andrea Bertotti and Livio Trusolino and Paolo Maria Comoglio and Carla Boccaccio},
  journal={Cancer research},
  year={2014},
  volume={74 6},
  pages={1857-69}
}
Metastatic colorectal cancer remains largely incurable, although in a subset of patients, survival is prolonged by new targeting agents such as anti-EGF receptor (anti-EGFR) antibodies. This disease is believed to be supported by a subpopulation of stem-like cells termed colon cancer-initiating cell (CCIC), which may also confer therapeutic resistance. However, how CCICs respond to EGFR inhibition has not been fully characterized. To explore this question, we systematically generated CCICs… CONTINUE READING