MET pathway as a therapeutic target.

Abstract

Dysregulation of mesenchymal-epithelial transition factor receptor tyrosine kinase pathway leads to cell proliferation, protection from apoptosis, angiogenesis, invasion, and metastasis. It can be dysregulated through overexpression, constitutive activation, gene amplification, ligand-dependent activation or mutation. New drugs targeting various mesenchymal-epithelial transition factor pathways are being investigated with promising results.

DOI: 10.1097/JTO.0b013e31819d6f91

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@article{Kim2009METPA, title={MET pathway as a therapeutic target.}, author={Eric S. Kim and Ravi Salgia}, journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer}, year={2009}, volume={4 4}, pages={444-7} }