MET overexpression assessed by new interpretation method predicts gene amplification and poor survival in advanced gastric carcinomas

@article{Ha2013METOA,
  title={MET overexpression assessed by new interpretation method predicts gene amplification and poor survival in advanced gastric carcinomas},
  author={Sang Yun Ha and Jeeyun Lee and So Young Kang and In-Gu Do and Soomin Ahn and Joon Oh Park and Won Ki Kang and Min Gew Choi and Tae Sung Sohn and Jae Moon Bae and Sung Hung Kim and Minji Kim and Seonwoo Kim and Cheol Keun Park and S H Ignatius Ou and Hee C Kim},
  journal={Modern Pathology},
  year={2013},
  volume={26},
  pages={1632-1641}
}
The establishment of better selection criteria for identifying sub-populations that may benefit from treatment is a key aspect of the development and success of targeted therapy. To investigate methods for assessing MET overexpression in gastric cancer, we conducted immunohistochemistry using a new anti-Total MET monoclonal antibody in a single-institution cohort of 495 patients. As antibody is directed against a membranous and/or cytoplasmic epitope, two interpretation methods were used: (1… CONTINUE READING
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References

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Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2011

MET expression and amplification in patients with localized gastric cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2011

Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2011