MET inhibitor PHA-665752 suppresses the hepatocyte growth factor-induced cell proliferation and radioresistance in nasopharyngeal carcinoma cells.

@article{Liu2014METIP,
  title={MET inhibitor PHA-665752 suppresses the hepatocyte growth factor-induced cell proliferation and radioresistance in nasopharyngeal carcinoma cells.},
  author={Tongxin Liu and Qi Li and Quanquan Sun and Yuqin Zhang and Hua Yang and Rong Wang and Longhua Chen and Wei Wang},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={449 1},
  pages={49-54}
}
Although ionizing radiation (IR) has provided considerable improvements in nasopharyngeal carcinoma (NPC), in subsets of patients, radioresistance is still a major problem in the treatment. In this study, we demonstrated that irradiation induced MET overexpression and activation, and the aberrant MET signal mediated by hepatocyte growth factor (HGF) induced radioresistance. We also found that MET inhibitor PHA-665752 effectively suppressed HGF induced cell proliferation and radioresistance in… CONTINUE READING