MET expression and copy number status in clear-cell renal cell carcinoma: prognostic value and potential predictive marker

@inproceedings{MacherGoeppinger2017METEA,
  title={MET expression and copy number status in clear-cell renal cell carcinoma: prognostic value and potential predictive marker},
  author={Stephan Macher-Goeppinger and Martina Keith and Volker Endris and Roland Penzel and Katrin E Tagscherer and Sascha A. Pahernik and Markus Hohenfellner and Humphrey A R Gardner and Carsten Gruellich and Peter Schirmacher and Wilfried Roth},
  booktitle={Oncotarget},
  year={2017}
}
Multiple targeted therapy for advanced clear-cell renal cell carcinoma (RCC) has substantially improved patient outcome, but complete remission is uncommon and many tumors eventually develop resistance. Mechanistic, preclinical, and early clinical data highlight c-Met / hepatocyte growth factor receptor as a promising target for RCC therapeutic agents.We have examined MET expression, frequency of MET gene copy gains and MET gene mutation in a large, hospital-based series of renal cell… CONTINUE READING
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