MET as a possible target for non-small-cell lung cancer.

  title={MET as a possible target for non-small-cell lung cancer.},
  author={Ahad A. Sadiq and Ravi Salgia},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={31 8},
Lung cancer is a heterogeneous group of disorders that is now being subdivided into molecular subtypes with dedicated targeted therapies. The MET receptor tyrosine kinase has been identified as aberrantly overexpressed, potentially having activating mutations, and amplified in certain subsets of lung cancers. The ligand hepatocyte growth factor (HGF) can also be overexpressed in lung cancer or expressed in stroma, and both the MET receptor and the HGF ligand can be targets for therapeutics… CONTINUE READING