MET amplification, protein expression, and mutations in pulmonary adenocarcinoma.

@article{Park2015METAP,
  title={MET amplification, protein expression, and mutations in pulmonary adenocarcinoma.},
  author={Seongyeol Park and Jaemoon Koh and Dong-Wan Kim and Miso Kim and Bhumsuk Keum and Tae Min Kim and Yoon Kyung Jeon and Doo Hyun Chung and Dae Seog DS Heo},
  journal={Lung cancer},
  year={2015},
  volume={90 3},
  pages={381-7}
}
OBJECTIVES MET amplification, protein expression, and splice mutations at exon 14 are known to cause dysregulation of the MET/HGF pathway. Our study aimed to confirm the relationship among MET amplification, protein expression, and mutations in pulmonary adenocarcinoma. MATERIALS AND METHODS MET protein expression by immunohistochemistry (IHC) and MET amplification by fluorescence in situ hybridization (FISH) were evaluated in 316 surgically resected lung adenocarcinomas. Patients were… CONTINUE READING
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