MET Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non-Small Cell Lung Carcinoma with Poor Prognosis.

@article{Tong2016METAA,
  title={MET Amplification and Exon 14 Splice Site Mutation Define Unique Molecular Subgroups of Non-Small Cell Lung Carcinoma with Poor Prognosis.},
  author={Joanna H M Tong and Sai F Yeung and Anthony W. H. Chan and Lau Ying Chung and Shuk Ling Chau and Raymond Wai Ming Lung and Carol Y K Tong and Chit Chow and Edith K. Y. Tin and Yau H Yu and Hui Li and Yi Pan and Wing Po Chak and Calvin S H Ng and Tony Shu Kam Mok and Ka Fai To},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2016},
  volume={22 12},
  pages={
          3048-56
        }
}
PURPOSE Activation of MET oncogene as the result of amplification or activation mutation represents an emerging molecular target for cancer treatment. We comprehensively studied MET alterations and the clinicopathologic correlations in a large cohort of treatment-naïve non-small cell lung carcinoma (NSCLC). EXPERIMENTAL DESIGN Six hundred eighty-seven NSCLCs were tested for MET exon 14 splicing site mutation (METΔ14), DNA copy number alterations, and protein expression by Sanger sequencing… CONTINUE READING

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