MET/HGF Signaling Pathway in Ovarian Carcinoma: Clinical Implications and Future Direction

  title={MET/HGF Signaling Pathway in Ovarian Carcinoma: Clinical Implications and Future Direction},
  author={Paulette Mhawech-Fauceglia and Michelle Afkhami and Tanja Pejovi{\'c}},
  booktitle={Pathology research international},
The HGF/MET signaling pathway is abnormal in numerous cancers including ovarian cancer. MET is expressed in 70% of human cancer and it is overexpressed in 30% of ovarian cases and cancer cell lines. The HGF/MET pathway plays a role in the initiation and progression of ovarian cancer through the most distinctive biologic program known as "invasive growth" which is accomplished through a coordinated activation of cell motility, invasiveness, degradation of extracellular matrix, survival, and… CONTINUE READING
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