MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

Abstract

Rap80 targets the breast cancer suppressor protein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB) to polyubiquitin structures at DNA double-strand breaks (DSBs). These DSB targeting events are essential for BRCA1-dependent DNA damage response-induced checkpoint and repair functions. Here, we identify MERIT40 (Mediator of Rap80… (More)
DOI: 10.1101/gad.1739609

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