MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.

@article{Shao2009MERIT40CB,
  title={MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks.},
  author={Genze Shao and Jeffrey Patterson-Fortin and Troy E. Messick and Dan Feng and Niraj M. Shanbhag and Yingqun Wang and Roger A. Greenberg},
  journal={Genes & development},
  year={2009},
  volume={23 6},
  pages={740-54}
}
Rap80 targets the breast cancer suppressor protein BRCA1 along with Abraxas and the BRCC36 deubiquitinating enzyme (DUB) to polyubiquitin structures at DNA double-strand breaks (DSBs). These DSB targeting events are essential for BRCA1-dependent DNA damage response-induced checkpoint and repair functions. Here, we identify MERIT40 (Mediator of Rap80 Interactions and Targeting 40 kD)/(C19orf62) as a Rap80-associated protein that is essential for BRCA1-Rap80 complex protein interactions… CONTINUE READING

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