MER-BCG (NSC-143769): immunogenicity and toxicity of single and repeated intradermal injections in dogs.

@article{Gray1979MERBCGI,
  title={MER-BCG (NSC-143769): immunogenicity and toxicity of single and repeated intradermal injections in dogs.},
  author={J. H. Gray and H. Esber and R. Fleischman and U. Schaeppi and D. McCracken and A. Bogd{\'e}n},
  journal={Journal of immunopharmacology},
  year={1979},
  volume={1 3},
  pages={
          377-98
        }
}
Intradermal injections of MER-BCG 0.1 mg or 0.2 mg at each of 10 multiple sites, led to local granuloma formation. The nodules reached approximately 10 mm in diameter, ulcerated and were accompanied by granulomatous changes in the regional lymph nodes. Six or twelve successive treatments (each including 10 injections) at 4 week intervals produced the same histopathological lesions but no changes in hematological and blood chemical parameters or general morphology and no changes in general… 

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