MEPE has the properties of an osteoblastic phosphatonin and minhibin.

  title={MEPE has the properties of an osteoblastic phosphatonin and minhibin.},
  author={Peter S. N. Rowe and Yoshinari Kumagai and Gabriel Guti{\'e}rrez and Ian Garrett and R W Blacher and Daren Rosen and J M Cundy and S Navvab and Di Chen and Marc Drezner and Leigh Quarles and Gregory R. Mundy},
  volume={34 2},
Matrix extracellular phosphoglycoprotein (MEPE) is expressed exclusively in osteoblasts, osteocytes and odontoblasts with markedly elevated expression found in X-linked hypophosphatemic rickets (Hyp) osteoblasts and in oncogenic hypophosphatemic osteomalacia (OHO) tumors. Because these syndromes are associated with abnormalities in mineralization and renal phosphate excretion, we examined the effects of insect-expressed full-length human-MEPE (Hu-MEPE) on serum and urinary phosphate in vivo… CONTINUE READING
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