MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.

@article{Fang2013MEN1IA,
  title={MEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.},
  author={Minggang Fang and Fen Xia and Meera Mahalingam and C M Virbasius and Narendra Wajapeyee and Michael R. Green},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 13},
  pages={2635-47}
}
Multiple endocrine neoplasia type 1 is a familial cancer syndrome resulting from loss-of-function mutations in the MEN1 gene. We previously identified the tumor suppressor MEN1 as a gene required for oncogene-induced senescence in melanocytes, raising the possibility that MEN1 is a melanoma tumor suppressor. Here we show that MEN1 expression is lost in a high percentage of human melanomas and melanoma cell lines. We find that melanocytes depleted of MEN1 are deficient in homologous… CONTINUE READING
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