MEN1 gene mutation analysis of sporadic adrenocortical lesions.

  title={MEN1 gene mutation analysis of sporadic adrenocortical lesions.},
  author={B G{\"o}rtz and Jurgen Roth and Ernst J. M. Speel and Astrid Kraehenmann and Ronald R. de Krijger and Xavier Mat{\'i}as-Guiu and Seraina Muletta-Feurer and K R{\"u}tmann and Parvin Saremaslani and Philipp U. Heitz and Paul Komminoth},
  journal={International journal of cancer},
  volume={80 3},
To clarify the role of the MEN1 gene in the tumorigenesis of sporadic adrenocortical tumors, we performed a molecular study on 35 adrenocortical lesions including 6 hyperplasias, 19 adenomas and 10 carcinomas. Loss of heterozygosity (LOH) of the MEN1 gene was assessed by PCR using an intragenic (D11S4946) and 2 flanking microsatellite markers (D11S4936, PYGM) and/or fluorescence in situ hybridization (FISH) with a 40-kb cosmid probe containing the MEN1 gene. The complete coding sequence of the… CONTINUE READING
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