MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism.

@article{Cetani2002MEN1GA,
  title={MEN1 gene alterations do not correlate with the phenotype of sporadic primary hyperparathyroidism.},
  author={Filomena Cetani and Elena Pardi and Edda Vignali and Simona Borsari and Antonella Picone and Luisella Cianferotti and Elena Ambrogini and Paolo Miccoli and Aldo Pinchera and Claudio Marcocci},
  journal={Journal of endocrinological investigation},
  year={2002},
  volume={25 6},
  pages={508-12}
}
Loss of heterozygosity (LOH) in the MEN1 region on chromosome 11q13 and MEN1 gene mutations have been found in a subset of sporadic parathyroid tumors. The question of whether these genetic abnormalities in the parathyroid tumors might influence the clinical and biochemical characteristics of primary hyperparathyroidism (PHPT) remains to be elucidated. The… CONTINUE READING