MEN, destruction and separation: mechanistic links between mitotic exit and cytokinesis in budding yeast.

@article{Yeong2002MENDA,
  title={MEN, destruction and separation: mechanistic links between mitotic exit and cytokinesis in budding yeast.},
  author={Foong May Yeong and Hong Hwa Lim and Uttam Surana},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2002},
  volume={24 7},
  pages={659-66}
}
Cellular events must be executed in a certain sequence during the cell division in order to maintain genome integrity and hence ensure a cell's survival. In M phase, for instance, chromosome segregation always precedes mitotic exit (characterized by mitotic kinase inactivation via cyclin destruction); this is then followed by cytokinesis. How do cells impose this strict order? Recent findings in budding yeast have suggested a mechanism whereby partitioning of chromosomes into the daughter cell… CONTINUE READING

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