MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.

@article{Sun2001MEKK2AW,
  title={MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.},
  author={Wenjing Sun and Kamala Kesavan and Brian C. Schaefer and Timothy P Garrington and Marti Ware and Nancy Lassignal Johnson and Erwin W. Gelfand and Gary Leon Johnson},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 7},
  pages={5093-100}
}
MEKK2 and MEKK3 are two closely related mitogen-activated protein kinase (MAPK) kinase kinases. The kinase domains of MEKK2 and MEKK3 are nearly identical, although their N-terminal regulatory domains are significantly divergent. By yeast two-hybrid library screening, we have identified MEK5, the MAPK kinase in the big mitogen-activated protein kinase 1 (BMK1)/ERK5 pathway, as a binding partner for MEKK2. MEKK2 expression stimulates BMK1/ERK5 activity, the downstream substrate for MEK5… CONTINUE READING

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2557–2565 MEKK2 Binds Lad/RIBP and MEK5 5100 by on D ecem er 8, 2006 w w w .jb.org D ow nladed fom

  • S. Faruki, R. L. Geahlen, D. J. Asai
  • J. Cell Sci
  • 2000
1 Excerpt

Cellular Interactions in Development: A Practical Approach (Hartley

  • P. L. Bartel, C. Chien, R. Sternglanz, S. Fields
  • D. A.,
  • 1993
1 Excerpt

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