MEK1 activation by PAK: a novel mechanism.

  title={MEK1 activation by PAK: a novel mechanism.},
  author={Electa R Park and Scott T. Eblen and Andrew D. Catling},
  journal={Cellular signalling},
  volume={19 7},
Extracellular signal-Regulated Kinase (ERK) controls a variety of cellular processes, including cell proliferation and cell motility. While oncogenic mutations in Ras and B-Raf result in deregulated ERK activity and proliferation and migration in some tumor cells, other tumors exhibit elevated ERK signaling in the absence of these mutations. Here we provide evidence that PAK can directly activate MEK1 by a mechanism distinct from conventional Ras/Raf mediated activation. We find that PAK… CONTINUE READING

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