MEK1/2 regulates microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte meiotic maturation.

@article{Yu2007MEK12RM,
  title={MEK1/2 regulates microtubule organization, spindle pole tethering and asymmetric division during mouse oocyte meiotic maturation.},
  author={Ling-Zhu Yu and Bo Xiong and Wen-xue Gao and Chun-Min Wang and Zhi-Sheng Zhong and Li-Jun Huo and Qiang Wang and Yi Hou and Kui Kui Liu and X. John{\'e} Liu and Heide Schatten and Da-Yuan Chen and Qing-Yuan Sun},
  journal={Cell cycle},
  year={2007},
  volume={6 3},
  pages={330-8}
}
It is well known that MAPK plays pivotal roles in oocyte maturation, but the function of MEK (MAPK kinase) remains unknown. We have studied the expression, subcellular localization and functional roles of MEK during meiotic maturation of mouse oocytes. Firstly, we found that MEK1/2 phoshorylation (p-MEK1/2, indicative of MEK activation) was low in GV (germinal vesicle) stage, increased 2h after GVBD (germinal vesicle breakdown), and reached the maximum at metaphase II. Secondly, we found that P… CONTINUE READING

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