MEK1/2 inhibitors in the treatment of gynecologic malignancies.

  title={MEK1/2 inhibitors in the treatment of gynecologic malignancies.},
  author={Caela R. Miller and Kate E. Oliver and John H. Farley},
  journal={Gynecologic oncology},
  volume={133 1},
Mitogen-activated protein kinases (MAPKs) are a family of ubiquitous eukaryotic signal transduction enzymes which link extracellular stimuli to intracellular gene expression pathways. While several three-tiered MAPK cascades have been elucidated in mammals, the prototypical pathway involves a network of proteins and kinases including the Rat sarcoma protein (Ras), mitogen-activated protein kinase kinase kinase (Raf or MAP3K), mitogen-activated protein kinase kinase (MEK or MAP2K), and… CONTINUE READING


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