MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells.

@article{Wang2009MEKMT,
  title={MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells.},
  author={Yue Wang and Meijing Wang and Aaron M. Abarbanell and Brent R. Weil and Jeremy L. Herrmann and Jiangning Tan and Nathan Michael Novotny and Arthur C Coffey and Daniel R. Meldrum},
  journal={Surgery},
  year={2009},
  volume={146 2},
  pages={198-205}
}
BACKGROUND Bone marrow mesenchymal stem cells (MSCs) may mediate their beneficial effects by paracrine mechanisms. Recently, we reported that tumor necrosis factor-alpha (TNF-alpha) increased the release of vascular endothelial growth factor (VEGF) from human MSCs and augmented transforming growth factor-alpha (TGF-alpha)-stimulated VEGF secretion. However, it is unknown whether TNF-alpha stimulates VEGF production via TNF receptor 1 (TNFR1) or 2 (TNFR2) and the mechanism by which TNF-alpha… CONTINUE READING

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