MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.

@article{Widmann1998MEKK1,
  title={MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis.},
  author={Christian Widmann and P{\"a}r Gerwins and Nancy Lassignal Johnson and Matthew B. Jarpe and Gary Leon Johnson},
  journal={Molecular and cellular biology},
  year={1998},
  volume={18 4},
  pages={2416-29}
}
MEK kinase 1 (MEKK1) is a 196-kDa protein that, in response to genotoxic agents, was found to undergo phosphorylation-dependent activation. The expression of kinase-inactive MEKK1 inhibited genotoxin-induced apoptosis. Following activation by genotoxins, MEKK1 was cleaved in a caspase-dependent manner into an active 91-kDa kinase fragment. Expression of MEKK1 stimulated DEVD-directed caspase activity and induced apoptosis. MEKK1 is itself a substrate for CPP32 (caspase-3). A mutant MEKK1 that… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS