MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury

@inproceedings{Lin2014MEKIR,
  title={MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury},
  author={Bin Lin and Yang Xu and Bin Zhang and Yong He and Yunqin Yan and Ming-Chang He},
  booktitle={Experimental and therapeutic medicine},
  year={2014}
}
The aim of this study was to investigate the effect of U0126 on the formation of glial scars following spinal cord injury (SCI) in a rat model. Ninety adult female Sprague-Dawley rats were divided randomly into sham injury (group I), SCI (group II) and U0126 treatment (group III) groups, and functional outcome was observed during the 4 weeks following the injury. The P1 and N1 latencies and P1-N1 amplitudes of somatosensory-evoked potentials (SEPs) were collected one day prior to surgery, on… CONTINUE READING
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