MEK inhibition impairs influenza B virus propagation without emergence of resistant variants.

@article{Ludwig2004MEKII,
  title={MEK inhibition impairs influenza B virus propagation without emergence of resistant variants.},
  author={Stephan Ludwig and Thorsten Wolff and Christina Ehrhardt and Walter Juergen Wurzer and Jens Reinhardt and Oliver Planz and Stephan Pleschka},
  journal={FEBS letters},
  year={2004},
  volume={561 1-3},
  pages={
          37-43
        }
}
Influenza A and B viruses are still a major worldwide threat. We demonstrate that influenza B virus infection induces signaling via the Raf/MEK/ERK cascade, a process required for efficient virus production. Expression of dominant-negative Raf and ERK mutants or treatment with a MEK inhibitor (U0126) strongly impaired viral propagation, while selective activation of the pathway resulted in increased virus titers. MEK inhibition appears to interfere with a distinct viral nuclear export process… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Similar Papers

Loading similar papers…