MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.

  title={MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.},
  author={Naidu G. M. Vegi and Josef Klappacher and Franz Oswald and Medhanie A Mulaw and Amit Mandoli and Verena N. Thiel and Shiva Bamezai and Kristin Feder and Joost H A Martens and Vijay P. S. Rawat and Tamoghna Mandal and Leticia Quintanilla-Martinez and Karsten Spiekermann and Wolfgang Hiddemann and Konstanze Doehner and Hartmut D{\"o}hner and Hendrik G. Stunnenberg and Michaela Feuring-Buske and Christian Buske},
  journal={Cell reports},
  volume={16 2},
Homeobox genes are known to be key factors in leukemogenesis. Although the TALE family homeodomain factor Meis1 has been linked to malignancy, a role for MEIS2 is less clear. Here, we demonstrate that MEIS2 is expressed at high levels in patients with AML1-ETO-positive acute myeloid leukemia and that growth of AML1-ETO-positive leukemia depends on MEIS2 expression. In mice, MEIS2 collaborates with AML1-ETO to induce acute myeloid leukemia. MEIS2 binds strongly to the Runt domain of AML1-ETO… CONTINUE READING
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