MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

  title={MEG3 long noncoding RNA regulates the TGF-β pathway genes through
formation of RNA–DNA triplex structures},
  author={Tanmoy Mondal and Santhilal Subhash and Roshan Vaid and Stefan Enroth and Sireesha Uday and Bj{\"o}rn Reinius and Sanhita Mitra and Arif Mohammed and Alva Rani James and Emily Hoberg and Aristidis Moustakas and Ulf Gyllensten and Steven J. M. Jones and Claes M. Gustafsson and Andrew H. Sims and Fredrik Westerlund and Eduardo Gorab and Chandrasekhar Kanduri},
  booktitle={Nature communications},
Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. We have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one of the chromatin-interacting lncRNAs, MEG3, we explore the mechanisms by which lncRNAs target chromatin. Here we show that MEG3 and EZH2 share common target genes, including the TGF… CONTINUE READING
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