MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures

@inproceedings{Mondal2015MEG3LN,
  title={MEG3 long noncoding RNA regulates the TGF-β pathway genes through
formation of RNA–DNA triplex structures},
  author={Tanmoy Mondal and Santhilal Subhash and Roshan Vaid and Stefan Enroth and Sireesha Uday and Bj{\"o}rn Reinius and Sanhita Mitra and Arif P. Mohammed and Alva Rani James and Emily R. Hoberg and Aristidis Moustakas and Ulf Gyllensten and Steven J. M. Jones and Claes M Gustafsson and Andrew H Sims and Fredrik Westerlund and Eduardo Gorab and Chandrasekhar Kanduri},
  booktitle={Nature communications},
  year={2015}
}
Long noncoding RNAs (lncRNAs) regulate gene expression by association with chromatin, but how they target chromatin remains poorly understood. We have used chromatin RNA immunoprecipitation-coupled high-throughput sequencing to identify 276 lncRNAs enriched in repressive chromatin from breast cancer cells. Using one of the chromatin-interacting lncRNAs, MEG3, we explore the mechanisms by which lncRNAs target chromatin. Here we show that MEG3 and EZH2 share common target genes, including the TGF… CONTINUE READING
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