MEF2C TRANSCRIPTION FACTOR IS ASSOCIATED WITH THE GENETIC AND EPIGENETIC RISK ARCHITECTURE OF SCHIZOPHRENIA AND IMPROVES COGNITION IN MICE

@article{Mitchell2018MEF2CTF,
  title={MEF2C TRANSCRIPTION FACTOR IS ASSOCIATED WITH THE GENETIC AND EPIGENETIC RISK ARCHITECTURE OF SCHIZOPHRENIA AND IMPROVES COGNITION IN MICE},
  author={Amanda C. Mitchell and Behnam Javidfar and Venu M Pothula and D. Ibi and E. Shen and Cyril J Peter and Lucy K. Bicks and Tristan Fehr and Y. Jiang and K. Brennand and R. Neve and J. Gonz{\'a}lez-Maeso and S. Akbarian},
  journal={Molecular psychiatry},
  year={2018},
  volume={23},
  pages={123 - 132}
}
  • Amanda C. Mitchell, Behnam Javidfar, +10 authors S. Akbarian
  • Published 2018
  • Biology, Medicine
  • Molecular psychiatry
  • Large-scale consortia mapping the genomic risk architectures of schizophrenia provide vast amounts of molecular information, with largely unexplored therapeutic potential. We harnessed publically available information from the Psychiatric Genomics Consortium, and report myocyte enhancer factor 2C (MEF2C) motif enrichment in sequences surrounding the top scoring single-nucleotide polymorphisms within risk loci contributing by individual small effect to disease heritability. Chromatin profiling… CONTINUE READING
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