MEF2 negatively regulates learning-induced structural plasticity and memory formation

@article{Cole2012MEF2NR,
  title={MEF2 negatively regulates learning-induced structural plasticity and memory formation},
  author={Christina J. Cole and Valentina Mercaldo and Leonardo Restivo and Adelaide P. Yiu and Melanie J Sekeres and Jin Hee Han and Gisella Vetere and Tetyana Pekar and Pablo J. Ross and Rachael Lee Neve and Paul W. Frankland and Sheena A. Josselyn},
  journal={Nature Neuroscience},
  year={2012},
  volume={15},
  pages={1255-1264}
}
Memory formation is thought to be mediated by dendritic-spine growth and restructuring. Myocyte enhancer factor 2 (MEF2) restricts spine growth in vitro, suggesting that this transcription factor negatively regulates the spine remodeling necessary for memory formation. Here we show that memory formation in adult mice was associated with changes in endogenous MEF2 levels and function. Locally and acutely increasing MEF2 function in the dentate gyrus blocked both learning-induced increases in… CONTINUE READING