MEF2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor NR4A1.

@article{Daems2014MEF2IR,
  title={MEF2 is restricted to the male gonad and regulates expression of the orphan nuclear receptor NR4A1.},
  author={Caroline Daems and Luc J Martin and Catherine Brousseau and Jacques J. Tremblay},
  journal={Molecular endocrinology},
  year={2014},
  volume={28 6},
  pages={886-98}
}
Leydig cell steroidogenesis is controlled by the pituitary gonadotropin LH that activates several signaling pathways, including the Ca(2+)/calmodulin kinase I (CAMKI) pathway. In other tissues, CAMKI regulates the activity of the myocyte enhancer factor 2 (MEF2) transcription factors. MEF2 factors are essential regulators of cell differentiation and organogenesis in numerous tissues but their expression and role in the mammalian gonad had not been explored. Here we show that MEF2 factors are… CONTINUE READING