MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways.

@article{AlKhalili2004MEF2AI,
  title={MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways.},
  author={Lubna Al-Khalili and Alexander V Chibalin and Mei Yu and Bertil Sj{\"o}din and Carolina Nyl{\'e}n and Juleen R Zierath and Anna Krook},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={286 6},
  pages={C1410-6}
}
The myocyte enhancer factor (MEF)2 transcription factor is important for development of differentiated skeletal muscle. We investigated the regulation of MEF2 DNA binding in differentiated primary human skeletal muscle cells and isolated rat skeletal muscle after exposure to various stimuli. MEF2 DNA binding activity in nonstimulated (basal) muscle cultures was almost undetectable. Exposure of cells for 20 min to 120 nM insulin, 0.1 and 1.0 mM hydrogen peroxide, osmotic stress (400 mM mannitol… CONTINUE READING

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The myocyte enhancer factor ( MEF)2 transcription factor is important for development of differentiated skeletal muscle .
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