MED GATA factors promote robust development of the C. elegans endoderm.

@article{Maduro2015MEDGF,
  title={MED GATA factors promote robust development of the C. elegans endoderm.},
  author={Morris F Maduro and Gina Broitman-Maduro and Hailey Choi and Francisco Carranza and Allison Chia-Yi Wu and Scott A Rifkin},
  journal={Developmental biology},
  year={2015},
  volume={404 1},
  pages={66-79}
}
The MED-1,2 GATA factors contribute to specification of E, the progenitor of the Caenorhabditis elegans endoderm, through the genes end-1 and end-3, and in parallel with the maternal factors SKN-1, POP-1 and PAL-1. END-1,3 activate elt-2 and elt-7 to initiate a program of intestinal development, which is maintained by positive autoregulation. Here, we advance the understanding of MED-1,2 in E specification. We find that expression of end-1 and end-3 is greatly reduced in med-1,2(-) embryos. We… CONTINUE READING
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