MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy.

@article{Neupane2016MECP2IA,
  title={MECP2 Is a Frequently Amplified Oncogene with a Novel Epigenetic Mechanism That Mimics the Role of Activated RAS in Malignancy.},
  author={Manish Neupane and Allison P. Clark and Serena Landini and Nicolai J. Birkbak and Aron Charles Eklund and Elgene Lim and Aed{\'i}n C. Culhane and William T. Barry and Steven E Schumacher and Rameen Beroukhim and Zoltan Szallasi and Marc Vidal and David E Hill and Daniel P. Silver},
  journal={Cancer discovery},
  year={2016},
  volume={6 1},
  pages={45-58}
}
UNLABELLED An unbiased genome-scale screen for unmutated genes that drive cancer growth when overexpressed identified methyl cytosine-guanine dinucleotide (CpG) binding protein 2 (MECP2) as a novel oncogene. MECP2 resides in a region of the X-chromosome that is significantly amplified across 18% of cancers, and many cancer cell lines have amplified, overexpressed MECP2 and are dependent on MECP2 expression for growth. MECP2 copy-number gain and RAS family member alterations are mutually… CONTINUE READING
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