MECHANISMS OF GENOTOXICITY OF PARTICLES AND FIBERS

@article{Schins2002MECHANISMSOG,
  title={MECHANISMS OF GENOTOXICITY OF PARTICLES AND FIBERS},
  author={Roel P.F. Schins},
  journal={Inhalation Toxicology},
  year={2002},
  volume={14},
  pages={57 - 78}
}
  • R. Schins
  • Published 1 January 2002
  • Chemistry, Medicine
  • Inhalation Toxicology
With regard to genotoxicity testing and cancer risk assessment, particles and fibers form a rather specific group among all toxicants. First, the physicochemical behavior of fibrous and nonfibrous particles is usually very different from that of nonparticulate, chemical carcinogens. Reactive oxygen species (ROS) are believed to play a major role in primary genotoxicity of particles, which may derive from their surface properties, the presence of transition metals, intracellular iron… 
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