MECHANISM OF THIOAMIDE ANTITHYROID DRUG ASSOCIATED HYPOPROTHROMBINEMIA

@article{Lipsky1988MECHANISMOT,
  title={MECHANISM OF THIOAMIDE ANTITHYROID DRUG ASSOCIATED HYPOPROTHROMBINEMIA},
  author={JamesJ. Lipsky and Mar{\'i}a Pilar Orgaz Gallego},
  journal={Drug Metabolism and Drug Interactions},
  year={1988},
  volume={6},
  pages={317 - 326}
}
  • J. Lipsky, M. Gallego
  • Published 1988
  • Biology, Medicine, Chemistry
  • Drug Metabolism and Drug Interactions
The thioamide class of antithyroid drugs has been associated with the development of hypoprothrombinemia. Two drugs in this class, propylthiouracil and methimazole, resemble the methyltetrazole-thiol leaving group of certain cephalosporin antibiotics. Both were found in vitro to inhibit the vitamin K dependent step in clotting factor synthesis, the gamma-carboxylation of glutamic acid with 50 per cent inhibitory concentrations of 2 mM for propylthiouracil and 0.1 mM for methimazole. Methimazole… 

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