MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation.

@article{Stacchini1999MEC1AM,
  title={MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation.},
  author={Alessandra Stacchini and Manuela Aragno and Antonella Vallario and Alda Alfarano and Paola Circosta and Daniela Gottardi and A Faldella and Giovanna Rege-Cambrin and Ulf Thunberg and Kenneth Nilsson and Federico Caligaris-Cappio},
  journal={Leukemia research},
  year={1999},
  volume={23 2},
  pages={127-36}
}
We report the establishment and characterization of two cell lines, MEC1 and MEC2, that grew spontaneously on two subsequent occasions from the peripheral blood (PB) of a patient with B-chronic lymphocytic leukemia (B-CLL) in prolymphocytoid transformation. The patient was EBV-seropositive, his leukemic cells were EBNA negative, but the spontaneously grown cell lines are EBNA-2 positive. In liquid culture MEC1 cells grow adherent to the vessel wall and as tiny clumps; MEC2 cells do not adhere… CONTINUE READING
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