ME/CFS, case definition, and serological response to Epstein-Barr virus. A systematic literature review

  title={ME/CFS, case definition, and serological response to Epstein-Barr virus. A systematic literature review},
  author={Willy Eriksen},
  journal={Fatigue: Biomedicine, Health \& Behavior},
  pages={220 - 234}
  • W. Eriksen
  • Published 16 August 2018
  • Medicine
  • Fatigue: Biomedicine, Health & Behavior
ABSTRACT Background: The levels of antibodies to Epstein–Barr virus (EBV) in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have been compared to healthy controls in many studies. However, the results are inconsistent. Purpose: The objective of this systematic literature review was to determine whether differences in EBV serology between ME/CFS patients and controls vary with the case definition that is used. Methods: MEDLINE, EMBASE, and earlier reviews were searched… 

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Serologic and immunologic responses in chronic fatigue syndrome with emphasis on the Epstein-Barr virus.

Analysis of reports to date shows that the mean titers of antibodies to viral capsid antigen and to early antigen are greater for patients with CFS than for healthy individuals; this is particularly evident in cases for which serial samples were tested.

Studies on the relationship between chronic fatigue syndrome and Epstein-Barr virus in Japan.

It was concluded that a relationship does exist between CFS and EBV and the EA-IgG/EBNA ratio correlated with the degree of fatigue.

Antibodies to Epstein-Barr Virus in Patients With Chronic Fatigue

EBV serologic patterns have little clinical usefulness in evaluating patients with chronic fatigue, and psychiatric morbidity was common in both groups, including mood disorders.

Human Herpesviruses in Chronic Fatigue Syndrome

A double-blind study to assess the possible involvement of the human herpesviruses HHV6, HHV7, Epstein-Barr virus, and cytomegalovirus in chronic fatigue syndrome patients compared to age-, race-, and gender-matched controls found no significant differences between the CFS and control patients.

Chronic fatigue syndrome: I. Epstein‐Barr virus immune response and molecular epidemiology

Lack of control of EBV outgrowth in vitro is correlated with antibody evidence of active infection in vivo in some patients with chronic fatigue syndrome and Western blot studies suggested that ill subjects made antibodies to lytic proteins more frequently than did healthy control subjects.

Chronic Fatigue Syndrome and Herpesviruses: the Fading Evidence.

Patients with symptomatology suggestive of CFS do not appear to have an increased frequency of these herpesviruses, as detected by culture or polymerase chain reaction, compared with controls, which argues against an ongoing active herpetic infection.

Human herpesvirus 6 and chronic fatigue syndrome.

Elevated HHV-6 titres suggests that this virus could be a cofactor in the pathogenesis of CFS.

Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV‐6 in post‐infective fatigue syndrome

Data do not support the hypothesis of ongoing or reactivated EBV, HHV‐6, or CMV infection in the pathogenesis of CFS.

High titers of anti‐epstein‐barr virus DNA polymerase are found in patients with severe fatiguing illness

It is suggested that antibodies against EBV DNAP may be a useful marker in delineating a subset of patients with severe fatiguing illness for appropriate treatment trials and for monitoring their outcomes.

Prevalence in the Cerebrospinal Fluid of the Following Infectious Agents in a Cohort of 12 CFS Subjects

To determine the prevalence of HHV-6,HHV-8, Epstein-Barr virus (EBV), cytomegalovirus (CMV), Mycoplasma species, Chlamydia species, and Coxsackie virus in the spinal fluid of a group of 12 patients with CFS, a large number of these agents are neurotrophic agents.