MDR1 single nucleotide polymorphism G2677T/A and haplotype are correlated with response to docetaxel-cisplatin chemotherapy in patients with non-small-cell lung cancer.

@article{Pan2009MDR1SN,
  title={MDR1 single nucleotide polymorphism G2677T/A and haplotype are correlated with response to docetaxel-cisplatin chemotherapy in patients with non-small-cell lung cancer.},
  author={Ji-hong Pan and Jin-xiang Han and Jian-mei Wu and Hai-nan Huang and Qing-zhong Yu and Li-jun Sheng},
  journal={Respiration; international review of thoracic diseases},
  year={2009},
  volume={78 1},
  pages={49-55}
}
BACKGROUND The multidrug resistance gene 1 (MDR1) encodes P-glycoprotein (P-gp), which plays an important role in mediating multidrug resistance to chemotherapeutic agents. MDR1 gene polymorphisms may have an impact on the expression and function of P-gp, thereby influencing the response to chemotherapy. OBJECTIVES To investigate whether the MDR1 2677 and 3435 genotypes are associated with the sensitivity of non-small-cell lung cancer (NSCLC) to docetaxel. METHODS In this study we… CONTINUE READING

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