MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients.

@article{Urcelay2006MDR1GS,
  title={MDR1 gene: susceptibility in Spanish Crohn's disease and ulcerative colitis patients.},
  author={Elena Urcelay and Juan Lu{\'i}s Mendoza and Maria del Carmen Santiago Martin and Ana Mas and Alfonso Mo{\~n}ux Mart{\'i}nez and Carlos Taxonera and Miguel Fern{\'a}ndez-Arquero and Manuel D{\'i}az-Rubio and Emilio G{\'o}mez de la Concha},
  journal={Inflammatory bowel diseases},
  year={2006},
  volume={12 1},
  pages={
          33-7
        }
}
BACKGROUND The multidrug resistance MDR1 gene codes for a membrane transporter associated with inflammatory bowel disease. The polymorphism Ala893Ser/Thr (G2677T/A) previously showed significant association with Crohn's disease (CD) and the Ile1145Ile (C3435T) with ulcerative colitis (UC). We studied the association of both polymorphisms in an independent population to reveal the impact of the MDR1 gene on predisposition to inflammatory bowel disease. METHODS Case-control study with 321 CD… CONTINUE READING

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