MDR1 expression identifies human melanoma stem cells.

  title={MDR1 expression identifies human melanoma stem cells.},
  author={Gilmor I. Keshet and Itamar Goldstein and Orit Itzhaki and Karen Cesarkas and Liraz Shenhav and Arkadi Yakirevitch and Avraham J. Treves and Jacob M Schachter and Ninette Amariglio and Gideon Rechavi},
  journal={Biochemical and biophysical research communications},
  volume={368 4},
ABC transporters are often found to be inherently expressed in a wide variety of stem cells, where they provide improved protection from toxins. We found a subpopulation of human melanoma cells expressing multidrug-resistance gene product 1 (MDR1). This fraction co-expresses the ABC transporters, ABCB5 and ABCC2 in addition to the stem cell markers, nanog and human telomerase reverse transcriptase (hTERT). The clonogenicity and self-renewal capacity of MDR1(+) melanoma cells were investigated… CONTINUE READING