MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia.

@article{Ho2008MDR1AB,
  title={MDR1 and BCRP1 expression in leukemic progenitors correlates with chemotherapy response in acute myeloid leukemia.},
  author={Maria M Ho and Donna Hogge and Victor Ling},
  journal={Experimental hematology},
  year={2008},
  volume={36 4},
  pages={433-42}
}
OBJECTIVE Overexpression of members of the adenosine triphosphate binding cassette (ABC) transporter superfamily has been implicated in multidrug resistance in cancer, but results in acute myeloid leukemia (AML) have been inconsistent. We investigated the expression and activity of ABC transporters in patient total blasts and subpopulations along the leukemic stem cell hierarchy. MATERIALS AND METHODS Using quantitative reverse transcriptase polymerase chain reaction, we measured expression… CONTINUE READING
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